Pesquisa | Portal de Pesquisa da BVS

1.

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Kato, Nobutaka; Comer, Eamon; Sakata-Kato, Tomoyo; Sharma, Arvind; Sharma, Manmohan; Maetani, Micah; Bastien, Jessica; Brancucci, Nicolas M; Bittker, Joshua A; Corey, Victoria; Clarke, David; Derbyshire, Emily R; Dornan, Gillian L; Duffy, Sandra; Eckley, Sean; Itoe, Maurice A; Koolen, Karin M J; Lewis, Timothy A; Lui, Ping S; Lukens, Amanda K; Lund, Emily; March, Sandra; Meibalan, Elamaran; Meier, Bennett C; McPhail, Jacob A; Mitasev, Branko; Moss, Eli L; Sayes, Morgane; Van Gessel, Yvonne; Wawer, Mathias J; Yoshinaga, Takashi; Zeeman, Anne-Marie; Avery, Vicky M; Bhatia, Sangeeta N; Burke, John E; Catteruccia, Flaminia; Clardy, Jon C; Clemons, Paul A; Dechering, Koen J; Duvall, Jeremy R; Foley, Michael A; Gusovsky, Fabian; Kocken, Clemens H M; Marti, Matthias; Morningstar, Marshall L; Munoz, Benito; Neafsey, Daniel E; Sharma, Amit; Winzeler, Elizabeth A; Wirth, Dyann F.

Nature ; 538(7625): 344-349, 2016 Oct 20.

Artigo em Inglês | MEDLINE | ID: mdl-27602946

2.

Structural and conformational determinants of macrocycle cell permeability.

Over, Björn; Matsson, Pär; Tyrchan, Christian; Artursson, Per; Doak, Bradley C; Foley, Michael A; Hilgendorf, Constanze; Johnston, Stephen E; Lee, Maurice D; Lewis, Richard J; McCarren, Patrick; Muncipinto, Giovanni; Norinder, Ulf; Perry, Matthew W D; Duvall, Jeremy R; Kihlberg, Jan.

Nat Chem Biol ; 12(12): 1065-1074, 2016 12.

Artigo em Inglês | MEDLINE | ID: mdl-27748751

3.

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.

Wawer, Mathias J; Li, Kejie; Gustafsdottir, Sigrun M; Ljosa, Vebjorn; Bodycombe, Nicole E; Marton, Melissa A; Sokolnicki, Katherine L; Bray, Mark-Anthony; Kemp, Melissa M; Winchester, Ellen; Taylor, Bradley; Grant, George B; Hon, C Suk-Yee; Duvall, Jeremy R; Wilson, J Anthony; Bittker, Joshua A; Dancík, Vlado; Narayan, Rajiv; Subramanian, Aravind; Winckler, Wendy; Golub, Todd R; Carpenter, Anne E; Shamji, Alykhan F; Schreiber, Stuart L; Clemons, Paul A.

Proc Natl Acad Sci U S A ; 111(30): 10911-6, 2014 Jul 29.

Artigo em Inglês | MEDLINE | ID: mdl-25024206

4.

Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.

Lukens, Amanda K; Heidebrecht, Richard W; Mulrooney, Carol; Beaudoin, Jennifer A; Comer, Eamon; Duvall, Jeremy R; Fitzgerald, Mark E; Masi, Daniela; Galinsky, Kevin; Scherer, Christina A; Palmer, Michelle; Munoz, Benito; Foley, Michael; Schreiber, Stuart L; Wiegand, Roger C; Wirth, Dyann F.

J Infect Dis ; 211(7): 1097-103, 2015 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-25336726

5.

Erratum: Structural and conformational determinants of macrocycle cell permeability.

Over, Björn; Matsson, Pär; Tyrchan, Christian; Artursson, Per; Doak, Bradley C; Foley, Michael A; Hilgendorf, Constanze; Johnston, Stephen E; Lee, Maurice D; Lewis, Richard J; McCarren, Patrick; Muncipinto, Giovanni; Norinder, Ulf; Perry, Matthew W D; Duvall, Jeremy R; Kihlberg, Jan.

Nat Chem Biol ; 13(8): 922, 2017 Jul 18.

Artigo em Inglês | MEDLINE | ID: mdl-28853740

6.

Discovery of small-molecule modulators of the Sonic Hedgehog pathway.

Schaefer, Giannina I; Perez, José R; Duvall, Jeremy R; Stanton, Benjamin Z; Shamji, Alykhan F; Schreiber, Stuart L.

J Am Chem Soc ; 135(26): 9675-80, 2013 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-23725514

7.

Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides.

Gerard, Baudouin; Lee, Maurice D; Dandapani, Sivaraman; Duvall, Jeremy R; Fitzgerald, Mark E; Kesavan, Sarathy; Lowe, Jason T; Marié, Jean-Charles; Pandya, Bhaumik A; Suh, Byung-Chul; O'Shea, Morgan Welzel; Dombrowski, Michael; Hamann, Diane; Lemercier, Berenice; Murillo, Tiffanie; Akella, Lakshmi B; Foley, Michael A; Marcaurelle, Lisa A.

J Org Chem ; 78(11): 5160-71, 2013 Jun 07.

Artigo em Inglês | MEDLINE | ID: mdl-23692141

8.

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries.

Mulrooney, Carol A; Lahr, David L; Quintin, Michael J; Youngsaye, Willmen; Moccia, Dennis; Asiedu, Jacob K; Mulligan, Evan L; Akella, Lakshmi B; Marcaurelle, Lisa A; Montgomery, Philip; Bittker, Joshua A; Clemons, Paul A; Brudz, Stephen; Dandapani, Sivaraman; Duvall, Jeremy R; Tolliday, Nicola J; De Souza, Andrea.

J Comput Aided Mol Des ; 27(5): 455-68, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23585218

9.

Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates.

Duvall, Jeremy R; Thomas, Joshua D; Bukhalid, Raghida A; Catcott, Kalli C; Bentley, Keith W; Collins, Scott D; Eitas, Timothy; Jones, Brian D; Kelleher, Eugene W; Lancaster, Kelly; Protopopova, Marina; Ray, Soumya S; Ter-Ovanesyan, Elena; Xu, Ling; Yang, Liping; Zurita, Jeffrey; Damelin, Marc; Toader, Dorin; Lowinger, Timothy B.

J Med Chem ; 66(15): 10715-10733, 2023 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-37486969

10.

Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody-Drug Conjugate for the Treatment of Cancer.

Toader, Dorin; Fessler, Shawn P; Collins, Scott D; Conlon, Patrick R; Bollu, Reddy; Catcott, Kalli C; Chin, Chen-Ni; Dirksen, Anouk; Du, Bingfan; Duvall, Jeremy R; Higgins, Stacy; Kozytska, Mariya V; Bellovoda, Kamela; Faircloth, Chelsey; Lee, David; Li, Fu; Qin, Liuliang; Routhier, Caitlin; Shaw, Pamela; Stevenson, Cheri A; Wang, Jason; Wongthida, Phonphimon; Ter-Ovanesyan, Elena; Ditty, Elizabeth; Bradley, Stephen P; Xu, Ling; Yin, Mao; Yurkovetskiy, Alexandr V; Mosher, Rebecca; Damelin, Marc; Lowinger, Timothy B.

Mol Cancer Ther ; 22(9): 999-1012, 2023 09 05.

Artigo em Inglês | MEDLINE | ID: mdl-37294948

11.

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

Lowe, Jason T; Lee, Maurice D; Akella, Lakshmi B; Davoine, Emeline; Donckele, Etienne J; Durak, Landon; Duvall, Jeremy R; Gerard, Baudouin; Holson, Edward B; Joliton, Adrien; Kesavan, Sarathy; Lemercier, Berenice C; Liu, Haibo; Marié, Jean-Charles; Mulrooney, Carol A; Muncipinto, Giovanni; Welzel-O'Shea, Morgan; Panko, Laura M; Rowley, Ann; Suh, Byung-Chul; Thomas, Meryl; Wagner, Florence F; Wei, Jingqiang; Foley, Michael A; Marcaurelle, Lisa A.

J Org Chem ; 77(17): 7187-211, 2012 Sep 07.

Artigo em Inglês | MEDLINE | ID: mdl-22853001

12.

Practical asymmetric synthesis of ß-hydroxy Î³-amino acids via complimentary aldol reactions.

Pandya, Bhaumik A; Dandapani, Sivaraman; Duvall, Jeremy R; Rowley, Ann; Mulrooney, Carol A; Ryba, Troy; Dombrowski, Michael; Harton, Marie; Young, Damian W; Marcaurelle, Lisa A.

Tetrahedron ; 67(34): 6131-6137, 2011 Aug 26.

Artigo em Inglês | MEDLINE | ID: mdl-21822337

13.

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Marcaurelle, Lisa A; Comer, Eamon; Dandapani, Sivaraman; Duvall, Jeremy R; Gerard, Baudouin; Kesavan, Sarathy; Lee, Maurice D; Liu, Haibo; Lowe, Jason T; Marie, Jean-Charles; Mulrooney, Carol A; Pandya, Bhaumik A; Rowley, Ann; Ryba, Troy D; Suh, Byung-Chul; Wei, Jingqiang; Young, Damian W; Akella, Lakshmi B; Ross, Nathan T; Zhang, Yan-Ling; Fass, Daniel M; Reis, Surya A; Zhao, Wen-Ning; Haggarty, Stephen J; Palmer, Michelle; Foley, Michael A.

J Am Chem Soc ; 132(47): 16962-76, 2010 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-21067169

14.

Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal.

Marian, Christine A; Stoszko, Mateusz; Wang, Lili; Leighty, Matthew W; de Crignis, Elisa; Maschinot, Chad A; Gatchalian, Jovylyn; Carter, Benjamin C; Chowdhury, Basudev; Hargreaves, Diana C; Duvall, Jeremy R; Crabtree, Gerald R; Mahmoudi, Tokameh; Dykhuizen, Emily C.

Cell Chem Biol ; 25(12): 1443-1455.e14, 2018 12 20.

Artigo em Inglês | MEDLINE | ID: mdl-30197195

15.

Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells.

Nagiec, Marek M; Duvall, Jeremy R; Skepner, Adam P; Howe, Eleanor A; Bastien, Jessica; Comer, Eamon; Marie, Jean-Charles; Johnston, Stephen E; Negri, Joseph; Eichhorn, Michelle; Vantourout, Julien; Clish, Clary; Musunuru, Kiran; Foley, Michael; Perez, Jose R; Palmer, Michelle A J.

Medchemcomm ; 9(11): 1831-1842, 2018 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-30542533

16.

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.

Duvall, Jeremy R; Bedard, Leanne; Naylor-Olsen, Adel M; Manson, Abigail L; Bittker, Joshua A; Sun, Wenye; Fitzgerald, Mark E; He, Zhenmin; Lee, Maurice D; Marie, Jean-Charles; Muncipinto, Giovanni; Rush, Diane; Xu, Deming; Xu, Huisheng; Zhang, Mingliang; Earl, Ashlee M; Palmer, Michelle A; Foley, Michael A; Vacca, Joseph P; Scherer, Christina A.

ACS Infect Dis ; 3(5): 349-359, 2017 05 12.

Artigo em Inglês | MEDLINE | ID: mdl-28215073

17.

Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.

Duvall, Jeremy R; VerPlank, Lynn; Ludeke, Barbara; McLeod, Sarah M; Lee, Maurice D; Vishwanathan, Karthick; Mulrooney, Carol A; Le Quement, Sebastian; Yu, Qin; Palmer, Michelle A; Fleming, Paul; Fearns, Rachel; Foley, Michael A; Scherer, Christina A.

Antiviral Res ; 131: 19-25, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27059228

18.

Synthesis of jenamidines A1/A2.

Snider, Barry B; Duvall, Jeremy R.

Org Lett ; 7(20): 4519-22, 2005 Sep 29.

Artigo em Inglês | MEDLINE | ID: mdl-16178573

19.

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.

Nagiec, Marek M; Skepner, Adam P; Negri, Joseph; Eichhorn, Michelle; Kuperwasser, Nicolas; Comer, Eamon; Muncipinto, Giovanni; Subramanian, Aravind; Clish, Clary; Musunuru, Kiran; Duvall, Jeremy R; Foley, Michael; Perez, Jose R; Palmer, Michelle A J.

PLoS One ; 10(3): e0120295, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25811180

20.

Termination of Mn(III)-based oxidative cyclizations by trapping with azide.